microRNA-29 expression in patients with Nasal polypi

Document Type : Full Length research Papers

Authors

1 Department of otorhinolaryngology - Fayoum university- Fayoum 63511- Egypt

2 Otorhinolaryngology, ENT Department Faculty of Medicine, Fayoum University, Egypt

3 Department of otorhinolaryngology - Faculty of medicine - Fayoum university- Fayoum

4 Department of Medical Microbiology and immunology - Fayoum university- Fayoum

5 Medical Biochemistry and Molecular Biology - Fayoum university- Fayoum

6 Department of Otorhinolaryngology-Faculty of Medicine - Fayoum University.

Abstract

Abstract
Introduction: In the ENT outpatient clinic, sinus polypi is a usual clinical condition. Complaints include sinus blockage, smell issues, anterior or posterior nasal discharge, and/or continuous facial discomfort extending more than twelve weeks in duration. nasal polyps originate usually from the ethmoid sinuses and expand into the nasal passageway. A category of non-coding RNAs are referred to as microRNAs (miRNAs). They have an impact on the regulation of how genes are expressed. In specific instances, microRNAs have the power to regulate transcription and initiate translation.
Aim of the study: to observe microRNA (29) expression in patients with sinus polypi.
Subjects and Methods: One hundred people participated in our study; fifty of them had sinus polyps and the other fifty were healthy. We recorded the patient's name, sex, age, chronic conditions, and nasal symptoms in our comprehensive ENT history. complaints citing sinus blockade, facial pain and odor. Three milliliters of venous blood were drawn from each individual in order to extract RNA and measure the expression of microRNA 29 using RT-PCR.
Results: The median (IQR) among individuals with sinonasal polypi is lower when it comes to a high level of microRNA (29) biomarker under expression.
Conclusions: This study discovered that patients with sinonasal polyps were related with a considerable underexpression of microRNA 29.

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Fayoum University Medical Journal
Volume 13, Issue 3
Surgical subspecialties
April 2024
Pages 142-149

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